Author's response to reviews Title:Rocuronium blockade reversal with sugammadex vs. neostigmine: randomized study in Chinese and Caucasian subjects Authors:
نویسندگان
چکیده
Xinmin Wu ([email protected]) Helle Oerding ([email protected]) Jin Liu ([email protected]) Bernard Vanacker ([email protected]) Shanglong Yao ([email protected]) Vegard Dahl ([email protected]) Lize Xiong ([email protected]) Casper Claudius ([email protected]) Yun Yue ([email protected]) Yuguang Huang ([email protected]) Esther Abels ([email protected]) Henk Rietbergen ([email protected]) Tiffany Woo ([email protected])
منابع مشابه
Rocuronium blockade reversal with sugammadex vs. neostigmine: randomized study in Chinese and Caucasian subjects
BACKGROUND This study compared efficacy and safety of the selective relaxant binding agent sugammadex (2 mg/kg) with neostigmine (50 μg/kg) for neuromuscular blockade (NMB) reversal in Chinese and Caucasian subjects. METHODS This was a randomized, active-controlled, multicenter, safety-assessor-blinded study (NCT00825812) in American Society of Anesthesiologists Class 1-3 subjects undergoing ...
متن کاملSugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients
BACKGROUND Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing rapid reversal of moderate (reappearance of T2) rocuronium-induced NMB. We investigated the efficacy and safety of sugammadex versus neostigmine in Korean patients. METHODS ...
متن کاملReversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine.
BACKGROUND Reversal of the residual effect of rocuronium or cisatracurium by neostigmine may be slow and associated with side-effects. This randomized, safety-assessor-blinded study compared the efficacy of sugammadex, a selective relaxant binding agent for reversal of rocuronium-induced neuromuscular block, with that of neostigmine for reversal of cisatracurium-induced neuromuscular block. The...
متن کاملSugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.
BACKGROUND Sugammadex is a modified [gamma] cyclodextrin compound, which encapsulates rocuronium to provide for a rapid reversal of residual neuromuscular blockade. We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound residual rocuronium-induced blockade than the commonly used cholinesterase inhibitors, edrophonium and neostigmine. METHODS ...
متن کاملReversal of neuromuscular blockade with sugammadex at the reappearance of four twitches to train-of-four stimulation.
BACKGROUND Doses of sugammadex required to reverse deep, moderate, and shallow rocuronium-induced neuromuscular blockade have been established. However, no adequate doses for the reversal of reappearance of four twitches of train-of-four (TOF) stimulation (threshold TOF-count-four) have been established. METHODS This single-center, randomized, controlled, double-blind, four-groups parallel-ar...
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تاریخ انتشار 2014